Author

Miten Jain

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Open access Oct 2026

A strategy for ionic current analysis of nanopore protein readouts

An integrated computational strategy for processing nanopore protein ionic current signals from synthetic protein constructs containing all 20 amino acids in controlled sequence contexts is developed, using a profile hidden Markov model to capture sequential structure of protein translocation.

Andrew J. Stein, Neda Ghohabi-Esfahani, Stuart G. Akeson et al. · bioRxiv · 0 citations

Open access Aug 2026

SALRR: Scalable Analysis of Long-Read RNA-Seq Enables Comprehensive Transcriptome Profiling in Human Brain

An integrated wet-lab and computational platform designed to overcome barriers to population-scale long-read RNA sequencing, providing a scalable, community-ready framework for isoform-resolved transcriptomics in neurodegeneration, aging, and complex brain disease.

C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al. · bioRxiv · 0 citations

Open access Sep 2026

Characterization of METTL3/14-mediated m6A modification in human transcriptome using Nanopore direct RNA sequencing

This study leveraged ONT to comprehensively profile bona fide m6A modifications in cellular RNAs at single-nucleotide resolution by integrating two direct RNA sequencing chemistries with the m6Anet and Dorado modification-detection models and establishes a robust transcriptome-wide framework for RNA modification detect...

Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla et al. · PLoS Genetics · 0 citations