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Mitchell R. McGill

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Open access Oct 2026

Loss of LKB1 protects against acetaminophen hepatotoxicity in mice through sex-specific mechanisms.

Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). We previously observed activation of liver kinase B1 (LKB1) in non-surviving patients with APAP-induced ALF. Thus, we hypothesized LKB1 is detrimental in APAP hepatotoxicity. To test our hypothesis, we overdosed hepatocyte-specific LKB1 knocko...

Debasree Bhadra, Jenna S. Caswell, Kathryn L. Smith et al. · 0 citations

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