Background The Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) is a key adaptor in Toll-like receptor signaling, classically functioning as a cytoplasmic bridging adaptor for Myeloid differentiation primary response 88 (MyD88) recruitment. While its role in inflammatory signaling is well establish...
Pramod Patidar, Rajat Atre, Mirza S. Baig· Frontiers in Immunology· 1 citation
Inflammation is essential for host defense and tissue repair, yet its dysregulation contributes to the development of numerous chronic diseases. Macrophages play a central role in these processes through their remarkable functional plasticity and ability to adopt pro-inflammatory or pro-resolving states. Nanoparticles...
Shreya Bharti, Alexander G. Obukhov, Sabahat Zafar et al.· Frontiers in Bioengineering...· 0 citations
Wheat bran supplementation attenuates HFD-induced metabolic disturbances and improves body weight regulation, lipid profiles and overall health and demonstrates its potential role as a functional dietary intervention in the prevention and management of obesity-related metabolic disorders.
Sirisha Nuti, S. Srinivasamurthy, Mainak Dutta et al.· Nutrition and Health· 0 citations
Background Alcoholic liver disease (ALD) remains a significant global health issue, marked by chronic liver injury and progressive accumulation of extracellular matrix (ECM), ultimately leading to fibrosis. A key driver of this fibrotic process is the activation of hepatic stellate cells (HSCs), largely influenced by i...
Pramod Patidar, Alexander G Obukhov, Sheikh A Tasduq et al.· Frontiers in Cell and Develo...· 0 citations
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