Open access
Aug 2026
Genetic innovation in coronaviruses driven by a viral nuclease
It is shown that non-structural protein-15 (NSP15), a nuclease encoded by coronaviruses, can drive the acquisition of a class of insertion mutations, and numerous examples of potential furin cleavage site acquisition and replacement through insertion mutation during the normal course of coronavirus replication are found.
C. Bianco, Alex C. Stabell, Manivel Lodha et al.
· bioRxiv · 0 citations