Open access
Jul 2026
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
SimSiam‐MuTF is introduced, a novel fine‐tuning framework to enhance the detection of resistance variants by explicitly aligning latent embedding distances with the corresponding shifts in binding affinity between WT and MT targets, which deepen the understanding of mutation‐induced resistance.
Xiaowen Hu, Pan Zhang, Shangqian Wu et al.
· Advancement of science · 0 citations