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Open access Sep 2026

Heterogeneity in the response to the metabolic environment drives fosfomycin heteroresistance

Heteroresistance is a form of antibiotic resistance in which a phenotypically unstable subpopulation of resistant cells coexists with a majority susceptible population. Many mechanisms of heteroresistance are unclear and the impact of the extracellular environment on this phenomenon is unknown. Studying fosfomycin hete...

Jacob E. Choby, D. Hufnagel, Mu-Qing Ma et al. · 0 citations
Open access Sep 2026

Combinatorial action of regulatory systems generates colistin heteroresistance

The sigma factor σE is identified as the source of heterogeneity in colistin resistance and the combinatorial action of regulatory systems, encompassing a heterogeneity generator and a distinct resistance generator, gives rise to colistin heteroresistance.

Jacob E. Choby, E. Crispell, Mu-Qing Ma et al. · 0 citations
Open access Sep 2026

Bacteriostatic lethality emerges from turgor-induced physiological stress

It is found that translation inhibition by bacteriostatic antibiotics induces intracellular turgor pressure buildup by perturbing physiological balance in E. coli, showing bacteriostasis as a physiologically unstable state and providing a systems-level framework for its lethality, enabling the rational design of optimi...

Tatsuya Akiyama, Minsu Kim · 0 citations

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