Open access
Sep 2026
Structural basis of lenacapavir-induced HIV-1 capsid defects during virion maturation
Long-acting lenacapavir (LEN) has emerged as a highly effective, potentially game-changing therapy for HIV treatment and prevention. Its mechanism of action in the early phase of HIV-1 replication, when the capsid directs key post-entry steps such as reverse transcription, nuclear import, and integration, has been well...
Hiroki Tanaka, R. Morita, Tomomasa Oka et al.
· Nature Communications · 0 citations