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Mingliang Shan

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Open access Oct 2026

Resistance mechanisms and translational bottlenecks in CAR-T cell therapy for pediatric acute lymphoblastic leukemia: a perspective

Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable remission rates exceeding 80% in relapsed/refractory pediatric B-cell acute lymphoblastic leukemia (B-ALL), yet 40–50% of patients eventually relapse within the first year. This therapeutic ceiling is not a single failure mode but the convergence...

Ji-Li Xu, Li-Li Sui, Wen-Zhe Yang et al. · 0 citations

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