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Ming Yang

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Book Open access Aug 2026

Natural Language-Powered Functional Protein Sequence and Structure Co-Design with Multi-Modal Knowledge Fusion

This work proposes a Protein sequence–structure–function Consistency Design model empowered by Natural Language function description, dubbed ProtcdNl, which expands the protein design space and ensures alignment with function-aware framework, achieving the design of novel, diverse proteins with high functional fidelity...

Ming Yang, Xin Zheng, Yi Li et al. · 0 citations
#protein folding Open access Aug 2026

Modality-chain reasoning enables multimodal protein modelling and design

ProteinReasoner is developed, a multimodal generative protein foundation model that sequentially connects amino acid sequence, evolutionary constraints and three-dimensional structure within a shared autoregressive architecture and suggests a general route towards reasoning across interdependent representations in othe...

Chaozhong Liu, Linlin Chao, Shaomin Ji et al. · 1 citation

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