Shikonin suppresses fibrotic phenotype and oxidative stress in keloid fibroblasts via EGFR-targeted AKT/STAT3/PTGS2 modulation.
Keloids are fibroproliferative disorders with excessive extracellular matrix (ECM) deposition, fibroblast hyperproliferation, oxidative stress, and a lack of effective therapies. Shikonin, a natural naphthoquinone, exhibits anti-tumor and antioxidant activities, yet its role in keloid fibroblasts (KFs) remains unclear....