The molecular mechanisms by which LBNCs' architecture modulates key inflammatory regulators, such as cytokine networks and oxidative pathways, to achieve superior therapeutic control are analyzed, positioning LBNCs as a transformative paradigm for refining the precision and efficacy of modern anti-inflammatory therapy.
Yumna Zaheer, Syeda Zunaira Bukhari, Unqa Mustafa et al.· Wiley Interdisciplinary Revi...· 0 citations
Development of nanomedicines that can cross blood-brain barrier (BBB) for effective multi-target mitigation of ischemic stroke (IS) is still challenging. Here, we report a hydroxylated poly(amidoamine) dendrimer-based delivery system co-loaded with the immunomodulator fibronectin (FN) protein and the antioxidant neurop...
Siqi Geng, Caiyun Zhang, Zhiqiang Wang et al.· Acta Biomaterialia· 0 citations
This work provides a promising "full-cycle" nanoplatform that synergistically integrates PTT, chemotherapy, and immunotherapy for both NPC treatment and prophylaxis and generates effective immune protection against subsequent tumor challenge.
Rui-Qi Ji, Yijun Mei, Zhiqiang Wang et al.· Advanced Healthcare Material...· 0 citations
The integration of dual-responsive PVCL nanogels, dual ICD induction strategies through combination of photothermo-chemotherapy, and biomimetic membrane cloaking for precision NPC theranostics and immune activation are presented.
Shanbin Wen, Yifan Huang, Xianghao Xiao et al.· ACS Applied Materials and In...· 0 citations
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