Author

Ming Lu

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Open access Jul 2026

CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression.

A CCR5-driven immune-metabolic-transcriptional axis in microglia that underlies synaptic deficits in depressive-like behaviors is indicated, offering potential targets for therapeutic intervention.

Ying-Ying Jiao, Zhu Zhu, Rui-An Wang et al. · Cell Reports · 0 citations

Jul 2026

Targeting of CH25H to boost p62-dependent autophagic degradation of α-synuclein in cell and mouse models of Parkinson's disease.

Insight is provided into the mechanisms underlying α-synuclein turnover and suggests promising avenues for disease-modifying interventions in synucleinopathies.

Xiwei Zhang, Rui-xue Han, Wen Zhang et al. · Science Translational Medici... · 0 citations