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Open access Oct 2026

Hypoglycemic Agent Targets and Susceptibility to Lower Respiratory Infection: A Pharmacogenomic Mendelian Randomization Study

Background/Objectives: Patients with type 2 diabetes face heightened risks of lower respiratory tract infections, but whether distinct glucose-lowering drug targets differentially alter pulmonary susceptibility remains unclear. We investigated how genetically proxied perturbations of major antidiabetic targets relate t...

Tai-Kang Yao, Nan Wu, Yan-Qiu Ma et al. · 0 citations
Open access Sep 2026

Pyridoxic Acid as a Novel Endogenous Biomarker for OAT-Mediated Clearance of Meropenem: A Population Pharmacokinetic Modeling and PK/PD-Response Analysis in Patients with Sepsis

PDA is a valuable translational biomarker for OAT-mediated clearance and is suggested to complement CLcr in characterizing meropenem clearance variability, establishing a key PD endpoint.

Zi-Han Lei, Hao Liang, Qin Cheng et al. · 0 citations

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