Pelletierine alleviates alcohol-induced intestinal injury: mediating LOXL2-dependent cGAS-STING signalling in ferroptosis and mitophagy.
ETHNOPHARMACOLOGICAL RELEVANCE Punica granatum L. (pomegranate), a traditional Chinese medicinal plant, has long been used in ethnic medical systems for the treatment of gastrointestinal disorders. Pelletierine (PEL), a piperidine alkaloid isolated from pomegranate root bark, has been reported to exert protective effec...