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Author

Mingjia Gao

2 papers indexed here

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Sep 2026

Structural Modification of Bifenox Derivatives: Discovery of Novel Diaryl Thioethers as Potent Insect Trehalase Inhibitors

To discover novel noncarbohydrate trehalase inhibitors, 62 bifenox derivatives were designed and synthesized in this study. Among them, diaryl thioether 2b-1 exhibited optimal trehalase inhibitory activity with 72.5% inhibition rate at 100 μM and a Ki value of 36.3 μM, superior to bifenox (56.5 μM). Insecticidal acti...

Xi-Ning Sun, Xi Jiang, Ming-Jia Gao et al. · 0 citations
Aug 2026

Discovery of 2-Cinnamoylbenzimidazoles as Novel Insect and Fungal Trehalose-6-Phosphate Phosphatase Inhibitors

Trehalose-6-phosphate phosphatase (TPP), a key enzyme in trehalose biosynthesis, represents a promising target for pest and fungal control due to the absence of TPP in higher animals. However, few TPP inhibitors have been reported, and broad-spectrum agents targeting both insects and fungi remain scarce. In this stud...

Xi Jiang, Mingjia Gao, Zhijun Zhang et al. · 0 citations

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