Ming-Hui Lin

Targeting ALDOA Lactylation Reverses Vascular Remodeling in Pulmonary Hypertension by Disrupting Actin Polymerization and YAP Activation.

BACKGROUND Maladaptive vascular remodeling is a hallmark of pulmonary hypertension (PH), and therapeutic strategies directly targeting the pathological activity of smooth muscle cells remain limited. Metabolic and epigenetic dysregulation are established drivers of PH, and lysine lactylation has emerged as a novel post...