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Ming-De Liu

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Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

ABSTRACT The conserved macrodomain 1 (Mac1) within coronavirus nsp3 reverses ADP-ribosylation of proteins and contributes to viral virulence. While Mac1 has been characterized in several coronaviruses, its role in porcine epidemic diarrhea virus (PEDV) remains unknown. Since D445 and N462 are functionally important res...

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · 0 citations

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