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Author

Minal Patel

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Open access Oct 2026

Dynamics of human cardiogenesis and its disruption in trisomy 21.

Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches1. Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a context-aware, resolution-agnostic niche classificat...

J. Cranley, Kazumasa Kanemaru, S. Bayraktar et al. · 0 citations
Open access Aug 2026

Multi-scale modeling of human tissues from spatial transcriptomics with TERRA

Spatial transcriptomics maps gene expression at cellular resolution, revealing how cells organize into multicellular niches. Yet computational analyses remain dataset-specific, without a transferable representation of tissue organization that generalizes across datasets, tasks and tissues or predicts how tissues behave...

Sebastian Birk, M. V. Sanian, Amirhossein Vahidi et al. · 4 citations · ⚡1

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