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Open access Oct 2026

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6-Mediated Deacetylation.

Astragaloside IV (AS-IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models. Despite these multi-target benefits, the molecular mechanisms underlying its podocyte-protective effects remain largely uncharacterized, particularly its p...

Qi-Yu Yue, C. Yong, Xin-Ran Wang et al. · 0 citations
Open access Oct 2026

Ophiopogonin D Suppresses Non-Small Cell Lung Cancer Progression by Targeting Exosomal MALAT1 to Enhance Dendritic Cell Maturation.

Tumor-immune cell crosstalk critically shapes the progression of non-small cell lung cancer (NSCLC), yet the mechanisms underlying exosome-mediated immune suppression remain incompletely understood. Here, we identify a previously unrecognized exosomal lncRNA-mediated immunoregulatory axis targeted by the natural compou...

Qin-Feng Zhou, Yang Guo, Lei Wang et al. · 0 citations

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