Open access
Sep 2026
RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNα via T and B cell crosstalk remodeling.
Backgrounds/Aims PEGylated interferon-α (PEGIFNα) shows promise in treating chronic hepatitis B (CHB), yet patient response remains suboptimal. While suppressing hepatitis B virus (HBV) antigens by RNA interference (RNAi) could enhance PEGIFNα efficacy in CHB patients, the underlying immunological mechanisms remain obs...
Wenjing Zai, Kong-Ying Hu, Meng-Ying He et al.
· Clinical and Molecular Hepat... · 0 citations