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Author

Min Shao

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Open access Sep 2026

Association Between Lactate Trajectories and Clinical Outcomes in Critically Ill Patients with Sepsis-Associated Liver Injury

Background: Sepsis-associated liver injury (SALI) is a severe complication of sepsis that significantly increases the risk of mortality in intensive care unit (ICU) patients. While lactate is recognized as a prognostic biomarker for sepsis, the predictive potential of dynamic lactate trajectories in patients with SALI...

Hong Wei, Jian Zhang, Si-Jie Yu et al. · 0 citations
Aug 2026

The mechanism of SOX4/IGF2BP3/TRIB3 axis inhibiting autophagy and aggravating liver injury in sepsis.

It was found that the SOX4/IGF2BP3/TRIB3 axis was upregulated in septic hepatocytes, and its knockdown alleviated LPS-induced injury and impaired autophagic flux, and this axis exacerbated LPS-induced hepatocyte injury by suppressing autophagic flux.

Wen-Jun Zhao, Jing Zhang, Liang Zhang et al. · 0 citations

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