A comprehensive cell fate map of mammalian embryogenesis has remained out of reach given the scale, cellular diversity, and non-deterministic nature of development in utero. Here, we use PEtracer to continuously install heritable genetic marks as development progresses, reconstructing lineage trees that resolve ∼75% of...
William N. Colgan, Luke W. Koblan, JoAnne Villagrana et al.· Cell· 2 citations
Many epigenetic regulators play essential roles in animal development, but precisely how they function across different cell types without clear sequence preferences remains a foundational challenge. Here, we employed single-cell RNA sequencing to survey the mutant phenotypes of 30 essential regulatory pathways across...
Yusuke Kijima, JoAnne Villagrana, Min-Ming Wang et al.· bioRxiv· 0 citations
Many epigenetic regulators play essential roles in animal development, but precisely how they function across different cell types without clear sequence preferences remains a foundational challenge. Here, we employed single-cell RNA sequencing to survey the mutant phenotypes of 30 essential regulatory pathways across...
Yusuke Kijima, JoAnne Villagrana, Min-Ming Wang et al.· bioRxiv· 0 citations
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