Author

Min-Min Xiang

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Review Sep 2026

The emerging cellular metal ions-immune axis in cancer.

Cancer immunotherapy is frequently hindered by the immunosuppressive tumor microenvironment. Although metal ions have been viewed as essential nutrients or cytotoxic payloads, emerging evidence reveals that they are potent immune modulators that orchestrate the cancer-immunity cycle. Here, we synthesize how ionic compe...

Sha Qin, Min-Min Xiang, Tania Tao et al. · Trends in Cell Biology · 0 citations

Review Open access Sep 2026

Immune checkpoints and immunoregulation in metabolic diseases and cancers: pathological mechanisms and therapeutic potential

This review comprehensively elucidates the pathophysiological mechanisms and translational potential of immune checkpoint regulation in obesity, diabetes, and thyroid disease while proposing novel directions for clinical intervention.

Min-Min Xiang, Shuang Liu, De-Sheng Xiao et al. · Signal Transduction and Targ... · 1 citation

Aug 2026

Adaptor AP4M1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis through USP15-mediated deubiquitination and MINK1-dependent phosphorylation.

It is shown that AP4M1 is markedly upregulated in HCC, correlates with unfavorable prognosis, and is functionally involved in driving HCC progression, providing a critical theoretical basis for AP4M1-targeted therapeutic strategies in HCC.

Yuan-Hao Peng, K. Kang, Xuanxuan Li et al. · Cancer Letters · 0 citations