Author

Min Ge

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Sep 2026

Discovery of Thiram-Inspired Thiocarbamate Derivatives as Novel Laccase Inhibitors against Sclerotium rolfsii

Peanut stem rot, caused by the soil-borne pathogen Sclerotium rolfsii, poses a significant threat to global peanut production and results in substantial yield losses. A series of thiocarbamate derivatives were synthesized and evaluated against ten phytopathogenic fungi. Over 50% showed broad-spectrum fungicidal activity at 40 mg/L. Notably, compound b6 exhibited superior activity against S. rolfsii (EC50 = 0.75 mg/L), surpassing Thiram (EC50 = 0.91 mg/L). In vivo assays confirmed robust protective and curative efficacies on peanut seedlings. b6 also demonstrated potent laccase inhibition (IC50 = 0.064 mmol/L), significantly outperforming l-cysteine (IC50 = 0.551 mmol/L) and PMDD-5Y (IC50 = 0.326 mmol/L). Mechanistic studies revealed that b6 disrupts fungal cell membrane integrity and induces intracellular ROS accumulation. Overall, b6 represents a promising antifungal lead compound for designing novel laccase inhibitor-based fungicides.

Rong Li, Yuan-Jian Huang, Min Ge et al. · Journal of Agricultural and... · 0 citations

Jul 2026

Design, Synthesis, and Antifungal Activity of Novel Thiazole-2-carboxamide Derivatives Bearing Flexible Diaryl Linkers as Succinate Dehydrogenase Inhibitors.

To develop eco-friendly succinate dehydrogenase inhibitors with good fungicidal activity, various diaryl-substituted thiazole-2-carboxamide derivatives were designed and synthesized based on structure-activity relationships (SARs) and molecular docking. At 20 mg/L, most target compounds exhibited ≥80% inhibition against Valsa mali, Botrytis cinerea, Curvularia lunata, and Phytophthora capsici. Notably, compound G33 showed potent activity against B. cinerea (EC50 = 0.17 mg/L) and P. capsici (EC50 = 0.42 mg/L), outperforming commercial fungicides thifluzamide and boscalid. At 100 mg/L, G33 effectively suppressed B. cinerea infection on strawberries. Mechanistic studies revealed that G33 disrupted hyphal morphology and ultrastructure, compromised cell membrane integrity, dissipated mitochondrial membrane potential, and inhibited mycelial growth. Enzyme activity assays, molecular docking, and molecular dynamics (MD) simulations further confirmed that G33 directly targets succinate dehydrogenase. Combined with favorable theoretical calculation results and low toxicity, G33 emerges as a promising lead compound for developing highly efficient and environmentally benign agricultural fungicides.

Chao Zhang, Min Ge, Yuan-Jian Huang et al. · Journal of Agricultural and... · 0 citations