Author

Min Gao

2 papers indexed here

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Open access Sep 2026

Pharmacologically Targeting DHODH-Dependent Pyrimidine Metabolism with HSA-Conjugated BRQ Suppresses Leukemogenesis

Background: Metabolic reprogramming is a hallmark of acute myeloid leukemia (AML) and provides a rich source of therapeutic vulnerabilities. Among these, de novo pyrimidine biosynthesis has emerged as an important metabolic dependency, yet its contribution to AML progression remains incompletely defined. DHODH, a rate-...

Xiao-Xu Zhang, Chang-Hao Tian, Yang Ding et al. · Cancers · 0 citations

#protein folding Sep 2026

Engineered Tumor-Homing Escherichia coli for Localized Hyaluronic Acid Degradation and Stromal Remodeling in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) accumulates vast amounts of hyaluronic acid (HA), generating a rigid, high-pressure stroma that blocks drug delivery and infiltration. Although hyaluronidase (HAase) can dismantle this barrier, systemic administration of HAase depletes HA from healthy tissues and causes dose-limi...

Shuai Gao, Ting-Ting Liu, Chang-Hao Tian et al. · Macromolecular Bioscience · 0 citations