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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Min Chen

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2026

Engineering a Monomeric Nanopore Scaffold for Multiplexed Protein Detection.

A general protocol for the molecular grafting of two peptide affinity motifs onto OmpG, followed by purification and characterization of the engineered construct, to generate a single-channel multiplex sensor is presented.

Joshua C. Foster, Min Chen · 0 citations
Open access Aug 2026

Single-Molecule Nanopore Profiling of p53-TAD’s Conformational Dynamics, Interactions, and Inhibition

The MspA nanopore platform demonstrated using the intrinsically disordered transactivation domain of tumor suppressor p53 (p53-TAD) showed that MspA can stably capture p53-TAD and resolve up to six distinct current states with frequent interconversions, revealing a rich conformational landscape.

David DeCoeur, Samantha A Schultz, Jian-Han Chen et al. · 0 citations

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