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Author

Miles Pourbaghi

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Aug 2026

Constrained Generative Design Frameworks For Computational Discovery of Target-Specific DARPin Candidates

This work established a robust framework for identifying and prioritizing high-confidence DARPin candidates for experimental validation, and identified mesothelin-targeting DARPin candidates with predicted structural confidences approaching those of a structurally validated picomolar-affinity binder.

Miles Pourbaghi, O. Elemento, M. Bradbury · 0 citations

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