Author

Mikel Garcia-Marcos

2 papers indexed here

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Oct 2026

The Gα-interacting protein RGS4 in dorsal root ganglia maintains molecular and behavioral maladaptations in murine pain models.

Regulator of G protein signaling 4 (RGS4) is a Gα subunit-interacting protein that modulates the functional responses of various G protein-coupled receptors (GPCRs) and that is present in several components of the nociceptive circuitry. Here, we found that RGS4 in lumbar dorsal root ganglia (DRGs) is required for the m...

R. Serafini, B. Giotti, A. Luebbers et al. · Science Signaling · 0 citations

Sep 2026

Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.

Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration-approved therapy directly targets fibrotic remodeling in the heart. To address this unmet clinical need, we used a multidimensional drug discovery pipeline centered on a human induced pluripotent stem cel...

Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al. · Science · 0 citations