Integrating genome-scale metabolic models into multi-scale simulations
Genome-scale metabolic models can predict how individual cells allocate resources and respond to their environment, yet few frameworks link single-cell metabolism to the spatial organisation of multicellular systems. Here we introduce PhysiCelldFBA, an extension of the PhysiCell agent-based framework that couples genom...
Marco Ruscone, Othmane Hayoun-Mya, R. Heiland et al.
· bioRxiv · 0 citations