Architectonic Spandrels in the Origin of Enzymatic Function
It is found that reverse folding algorithms are unable to energetically minimize evolutionary conserved frustration at specific residues, even when detrimental to overall structural stability, and it is proposed that these frustration hotspots act as architectural spandrels, inherent physical constraints of the fold that evolution subsequently co-opts for function.
Miriam Poley-Gil, Miguel Fernández-Martín, Alin Banka et al.
· bioRxiv · 2 citations