Author

Michelle M. Chan

2 papers indexed here

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Open access Sep 2026

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

ABSTRACT The mature mammalian lung contains ∼50 different cell types that are located in precise positions along and around the airway epithelial tree. Here, we apply spatial transcriptomics to early embryonic mouse lungs to investigate how these spatial patterns are progressively established during development. Specif...

Peng-Fei Zhang, Benjamin K. Law, Niles Huang et al. · Advancement of science · 0 citations

Open access Sep 2026

Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability.

p53 plays a central role in the DNA damage response, inducing repair, cell-cycle arrest or apoptosis. Its loss is associated with replication stress and genomic instability. While several underlying mechanisms were suggested, the primary triggers of catastrophic genomic events like chromothripsis, a known driver of tum...

Wisam Zaatra, George Philippos, Petr Smirnov et al. · Molecules and Cells · 1 citation