Author

Michel Baudry

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Review Open access Sep 2026

Extracellular Vesicle Communication in the Central Nervous System: Mechanisms, Disease States, and Therapeutic Opportunities

Extracellular vesicles (EVs) are increasingly recognized as regulated mediators of intercellular communication in the central nervous system (CNS), transferring proteins, lipids, metabolites, and nucleic acids among neurons, glia, and other cells. EV communication comprises a complex integrated pathway that includes ve...

Xiao-Ning Bi, Hanna Gootin, Wen-Yue Su et al. · Bioengineering · 0 citations

Open access Aug 2026

Calpain-2 inhibition prevents pressure overload-induced lysosomal cathepsin release and cardiac hypertrophy.

AIMS Dysregulated calpains and cathepsins contribute to adverse cardiac remodeling following chronic pathological stress, but their interplay and the specific contributions of the classical calpain isoforms remain undefined. Here, we tested whether calpain-2 initiates a lysosome-cathepsin proteolytic axis that promotes...

Anna Martí-Boltaina, D. Aluja, Sara Delgado-Tomás et al. · Life Science · 0 citations

2026

Extracellular Vesicles in Angelman Syndrome: Expanding UBE3A Role beyond a Cell Autonomous Mechanism

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of maternal UBE3A, an E3 ubiquitin ligase essential for neuronal development, synaptic plasticity, and cognitive function. AS has traditionally been viewed as a cell-autonomous disorder in which intracellular UBE3A deficiency drives neuro...

Eduardo Penna, Michel Baudry, Xiao-Ning Bi · Journal of experimental neur... · 0 citations