Mitochondria arose from the endosymbiosis of a bacterium with an archaea-related host cell about 2 billion years ago. To understand their origins and evolution, we compared experimentally defined mitoproteomes from the MitoCarta Tree of Life project. Across eight organisms, we identified 8,619 distinct mitochondrial pr...
Michael Z. Chen, Jonathan A. Stefely, Eric G. Bardon et al.· Cell· 9 citations
Trypanosoma brucei and Leishmania tarentolae are model kinetoplastids whose mitochondria contain a unique DNA network, kinetoplast DNA (kDNA), and exhibit specialized features, including developmental remodeling and RNA editing. By integrating mass spectrometry-based protein correlation profiling with published dataset...
Andres F. Vacas, Md Solayman, Sarah E. Calvo et al.· Molecules and Cells· 4 citations
SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...
Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al.· Molecules and Cells· 2 citations
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