Author

Michael W. Beresford

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Review Open access Oct 2026

Juvenile-onset systemic lupus erythematosus in the treat-to-target era: recent advances in outcome assessment

Juvenile-onset systemic lupus erythematosus (jSLE) is a rare, severe multisystem autoimmune/inflammatory disease associated with early morbidity, cumulative treatment toxicity, and long-term organ damage. In this context, outcome assessment is central to both clinical care and research, yet remains particularly chall...

Valentina Natoli, Sarah Wright, Michael W. Beresford et al. · Pediatric Rheumatology Onlin... · 0 citations

Open access Aug 2026

The private truncating Toll-like receptor 7 p.Glu834* variant associates with juvenile-onset systemic lupus erythematosus and pathological cytokine expression in vitro.

OBJECTIVES The X chromosome-linked Toll-like receptor (TLR)7 gene contributes to type I interferon (IFN) expression in systemic lupus erythematosus (SLE). Recently, ultra-rare variants in TLR7 have been linked with Mendelian forms of SLE. METHODS Targeted new-generation sequencing was used to identify TLR7 coding var...

Y. Renaudineau, J. Hawkes, Katarzyna Mizgalska et al. · Annals of the Rheumatic Dise... · 0 citations