Author

Michael T. Spiotto

2 papers indexed here

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Sep 2026

Abstract B083: Mutant KRAS cooperates with the hypoxic tumor microenvironment to drive immunosuppressive macrophages via a paracrine PGE2/GM-CSF axis

Hypoxia is known to drive an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC). However, the underlying immunosuppressive mechanisms remain unclear. Here, we hypothesized that hypoxia-induced factors secreted from tumor cells promoted immunosuppressive macrophages in PDAC. We tr...

Matthew T. Cribb, Ayeisha N. Colón-Ortiz, Sahar Fattani et al. · Cancer Research · 0 citations

Open access Sep 2026

Paired analysis of primary adenoid cystic carcinoma and derived cell lines reveals a mesenchymal and stem-like shift associated with therapy resistance.

Adenoid cystic carcinoma (ACC) is a salivary gland malignancy characterized by slow but persistent growth, frequent local recurrence, and late metastatic progression. Patients with unresectable, recurrent, or metastatic disease have limited therapeutic options. Efforts to identify effective therapeutic targets have bee...

Tatiana V. Karpinets, Y. Mitani, Michael T. Spiotto et al. · Oral Oncology · 0 citations