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Michael T. A. Nguyen

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Sep 2026

Engineered Orthogonal Translation Systems from Metagenomic Libraries Expand the Genetic Code

Genetic code expansion with noncanonical amino acids (ncAAs) opens new opportunities for the design and engineering of proteins by broadening their chemical repertoire. Unfortunately, ncAA incorporation into proteins is limited both by a small collection of orthogonal aminoacyl-tRNA synthetases (aaRSs) and tRNAs and...

Kosuke Seki, Michael T. A. Nguyen, Petar I. Penev et al. · 0 citations

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