Open access
Jul 2026
Using enantioselective biosensors to evolve asymmetric biocatalysts.
This work evolves enantioselective transcription factors that convert enzyme-catalyzed enantiomer concentrations into programmable gene expression outputs, focusing on imine reductases, and designs a genetic circuit that enables TF generation within weeks.
Simon d’Oelsnitz, Wantae Kim, Nicole N Zhao et al.
· Nature Chemical Biology · 7 citations