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Michael Seifert

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Open access Sep 2026

Antibody-TLR3 agonist-conjugates program the tumor microenvironment and induce immune responses leading to tumor regression in experimental EGFRvIII-positive glioma.

It is revealed that RICIA is internalized by glioma cells via EGFRvIII-mediated endocytosis and induces a TLR3-dependent type I interferon response.

Alexander Hagstotz, Isabell Schau, Michael Seifert et al. · 0 citations

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