Author

M. Payne

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Open access Oct 2026

Differential sensitivity of k-mer based identification tools using closely related database sequences affects relative abundance estimation

Deep metagenomic sequencing is increasingly used for lineage profiling of complex biological mixtures, including applications such as wastewater virus surveillance and microbiome profiling. For profiling, sequence read sets are compared against a database of reference sequences to identify component genetic lineages, a...

Annie J. Forster, M. Payne, R. Rockett et al. · bioRxiv · 0 citations

Open access Aug 2026

Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli

A prophage-encoded small RNA, HnrS, is identified that functions as an anti-silencing factor by targeting the H-NS paralogue Hha, thereby modulating Hha–H-NS repression of virulence loci including the LEE type III secretion system.

Pranita Poudyal, Brandon M. Sy, Daniel G. Mediati et al. · PLoS Pathogens · 0 citations