BRCAness in FLT3-ITD AML confers vulnerability to PARP inhibition
BReast CAncer ( BRCA1 and BRCA2 ) is a tumor suppressor gene that plays an important role in the repair of double strand DNA break (DSB) via error-free homologous recombination (HR). BRCA1 and BRCA2 mutations induce vulnerability to PARP inhibition, known as synthetic lethality, in breast and ovarian cancers...