T88. LARGE-SCALE LYMPHOBLASTOID CELL LINE TRANSCRIPTOMIC PROFILING OF AUTISM RECAPITULATES PROTEIN FOLDING AND MITOCHONDRIAL ALTERATIONS
Background Autism spectrum disorder (ASD) is a common, heritable, polygenic neurodevelopmental disorder, with hundreds of robustly associated risk genes and loci. Transcriptomic profiling of post-mortem cortex has identified characteristic ASD molecular signatures, including upregulation of protein folding pathways and...