Open access
Aug 2026
A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate
Abstract Background Glioblastomas are characterized by the Warburg effect, driven by upregulation of pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase complex (PDC), leading to lactate accumulation. Dichloroacetate (DCA) is a potent and safe PDK inhibitor that crosses the blood-brain barrier, r...
Carolyn O. Dirain, Stuart A. Grossman, Xiao-Bu Ye et al.
· Neuro-Oncology Advances · 1 citation