Michael G. Callahan

SuSiNE: Genetic fine-mapping with signed functional priors and multi-basin ensembling

SuSiNE (Sum of Single Non-central Effects), a SuSiE extension incorporating signed functional annotations through a prior-mean channel, µ0 = ca, while preserving effect conjugacy, credible sets, and summary-statistic sufficiency is introduced, which lets the method use directional predictions from AI sequence models or...