Author

Michael Bader

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

Serotonin (5-HT) regulates neurodevelopment and behavior. Whereas central 5-HT is synthesized by tryptophan hydroxylase (TPH)-2, the TPH1 isoform produces 5-HT peripherally. Although these systems are anatomically segregated, TPH1 gene polymorphisms have been linked to neuropsychiatric vulnerability, suggesting that pe...

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · Brain, behavior, and immunit... · 0 citations

Open access Sep 2026

Effects of Constitutive Depletion or Excess of Serotonin during Development on the Maturation of Prefrontal Monoaminergic Circuits

Serotonin (5-hydroxytryptamine; 5-HT) is a critical neuromodulatory morphogen-like signal that governs prenatal cortical circuit assembly, and altered 5-HT signaling is implicated in a wide range of psychiatric disorders. Yet the structural consequences of lifelong 5-HT imbalance during the initial blueprinting phase...

Marta C. F. Samina, Maria Stanciu, Thibault Merkelijn et al. · ACS Chemical Neuroscience · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations