Author

Michael B. Stout

2 papers indexed here

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Review Oct 2026

X and Y chromosomes as determinants of aging and disease.

This Review integrates mechanistic advances in sex chromosome biology-including escape from X chromosome inactivation, X reactivation, parent-of-X-origin, X-skew, X- and Y-linked gene functions, and Y loss-with aging, neurologic disease, immunity, cancer, and cardiometabolic disease.

Dena B. Dubal, F. Ambrosio, Michael B. Stout et al. · Science · 0 citations

Open access Sep 2026

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

Ovarian aging underpins infertility, systemic morbidity, and mortality in women. Stromal fibrosis is implicated in ovarian aging but has not been defined in the human ovary in situ. We integrated shear wave elastography (SWE), extracellular matrix (ECM) neoepitope fingerprinting, and single-cell RNA sequencing of folli...

L. Hughes, E. Zaniker-Gomez, P. Devrukhkar et al. · Research Square · 0 citations