Open access
Sep 2026
Targeted BRD4 degradation by multivalent dendrimer-based PROTAC and its combined effects with chemotherapy on colon cancer.
Chemoresistance, often driven by aberrant transcriptional and epigenetic mechanisms, remains a significant barrier to effective colon cancer therapy. This study introduces a dendrimer-based proteolysis-targeting chimera (PROTAC) system, JTP, generated by conjugation of polyamidoamine (PAMAM-G4) dendrimer with 4-hydroxy...
Ramalingam Sharmila, Chi-Iong Weng, I-Lin Lu et al.
· Biomaterials · 0 citations