Ovarian cancer remains a major cause of gynecological cancer-related mortality, highlighting the need for novel therapeutic strategies capable of enhancing antitumor activity while targeting multiple mechanisms involved in tumor progression. Everolimus, an inhibitor of the mammalian target of rapamycin pathway, and car...
Mete Hakan Karalök, Burcu Biltekin, E. Karci et al.· International Journal of Mol...· 0 citations
Background: Anti-Müllerian hormone (AMH) is a key biomarker of ovarian reserve, reflecting the quantity of the remaining follicular pool. While chronological age is the primary determinant of AMH concentrations, emerging evidence suggests that vitamin D, vitamin B12, folate, and iron metabolism parameters may also infl...
Mete Hakan Karalök, Bağnu Dündar, Ayhan Parmaksız et al.· Journal of Clinical Medicine· 0 citations
Background: Fibroblast growth factor 23 (FGF23) and α-Klotho are key regulators of mineral metabolism and bone homeostasis; however, their combined diagnostic value in postmenopausal osteoporosis remains incompletely understood. This study investigated the associations of serum FGF23, α-Klotho, and the FGF23/α-Klotho r...
Mete Hakan Karalök, N. Mısırlıoğlu, Oznur Dundar Akin et al.· Journal of Clinical Medicine· 0 citations
Organelle-selective autophagy is an important regulator of tumor adaptation, immune signaling, and therapeutic resistance. By directing specific intracellular cargos to lysosomal degradation, selective autophagy pathways determine whether organelle damage is eliminated or remains available to innate immune sensors. In...
Ayhan Bilir, Berna Yıldırım, Mete Hakan Karalök· International Journal of Mol...· 0 citations
In just over a decade, in vitro modeling of the female reproductive tract has advanced from planar monolayers of immortalized cells to self-organizing epithelial organoids and, most recently, to increasingly complex multicellular and multicompartment 3D models, including assembloids that combine organoids with addition...
Mete Hakan Karalök, Burcu Biltekin, Turgay Barut et al.· Cells· 0 citations
Objective: Anti-Müllerian hormone (AMH) is the most widely used biochemical marker of ovarian reserve, but its associations with other reproductive hormones are usually examined one hormone at a time and without accounting for values reported at the assay floor. This study examined the associations between serum AMH an...
Mete Hakan Karalök, Bağnu Dündar, Ayhan Parmaksız et al.· Metabolites· 0 citations
Background: Anti-Müllerian hormone (AMH) is widely used as a marker of ovarian reserve and is strongly influenced by chronological age. Although inflammation has been implicated in ovarian aging and follicular dysfunction, whether routinely measured peripheral inflammatory markers provide additional information regardi...
Mete Hakan Karalök, Bağnu Dündar, Ayhan Parmaksiz et al.· Biomedicines· 0 citations
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