This review examines the comparative advantages of peptide-based architectures, including reduced molecular weight, access to challenging interfaces, and expansion of the addressable E3 ligase repertoire, against persistent translational barriers in proteolytic stability, membrane permeability, immunogenicity, and manu...
Walaa S. Aburayan, Ibrahim A. Alradwan, Beshair A. Alsaffar et al.· Pharmaceutics· 0 citations
Overall, site-specific integration provides a framework for linking CAR placement to therapeutic function, but no single locus or integration strategy is universally optimal and clinical evidence remains limited relative to the expanding preclinical landscape.
Hala Aldahshan, Abeer Al-Hubaysh, Dimah K. Alrabiah et al.· Biomedicines· 0 citations
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