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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Mengxia Zhang

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Aug 2026

PGAM5-mediated VDAC1 oligomerization Facilitates Ponatinib-Induced Cardiotoxicity via Disrupting the Mitophagy-Mitochondrial unfolded protein response Synergistic Defense Crosstalk.

These findings identify the PGAM5/VDAC1 axis as a key mechanism linking ponatinib stress to coordinated failure of MQC in the heart and targeting PGAM5-dependent VDAC1 oligomerization may represent a potential strategy for limiting ponatinib-associated cardiotoxicity.

Yuyu Li, Dandan Yuan, Haitao Zhou et al. · 0 citations

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