Heterogeneous progression of AT(N) biomarkers in data-driven subtypes of Alzheimer’s disease
Alzheimer’s disease (AD) exhibits substantial heterogeneity in brain atrophy patterns and progression rates. Data-driven subtyping based on the Subtype and Stage Inference (SuStaIn) model has identified distinct MRI-derived subtypes, but the longitudinal dynamics of these subtypes within the AT(N) framework remain...